(E/Z) -Rigosertib sodium
Product Specifications
CAS Number
1225497-78-8
Target
PLK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9982
Bioactivity
ON-01910 is a non-ATP-competitive PLK1 inhibitor (IC50 of 9 nM, in a cell-free assay) . It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Smiles
[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Molecular Formula
C21H24NNaO8S
Molecular Weight
473.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2096758-01 0.1 mL
Biotin-Linked Polyclonal Antibody to GRB2 Associated Binding Protein 1 (GAB1)
Ask
View Details