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AChE/BChE/BACE-1-IN-2

Product Specifications

CAS Number

1877000-20-8

Target

ROS Kinase, Cholinesterase (ChE), Beta-Secretase, Others

Related Pathways

Neuroscience, Tyrosine Kinase/Adaptors, Others

Bioactivity

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active AChE, BACE-1, and BChE inhibitor with IC50 values of 0.069, 0.097, and 0.127 μM against hAChE, hBACE-1, and hBChE, respectively. It exhibits remarkable antioxidant potential, considerable binding capability towards PAS-AChE, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress with excellent brain permeation [1].

Smiles

C(N1CC(NCC2=C(F)C=C(F)C=C2)CC1)C3=CC=CC=C3

Molecular Formula

C18H20F2N2

Molecular Weight

302.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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