AChE/BChE/BACE-1-IN-2
Product Specifications
CAS Number
1877000-20-8
Target
ROS Kinase|||Cholinesterase (ChE) |||Beta-Secretase|||Others
Related Pathways
Neuroscience|||Tyrosine Kinase/Adaptors|||Others
Bioactivity
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active AChE, BACE-1, and BChE inhibitor with IC50 values of 0.069, 0.097, and 0.127 ?M against hAChE, hBACE-1, and hBChE, respectively. It exhibits remarkable antioxidant potential, considerable binding capability towards PAS-AChE, potential disassembly of A? aggregates, and neuroprotective activity against A?-induced stress with excellent brain permeation [1].
Smiles
C(N1CC(NCC2=C(F)C=C(F)C=C2)CC1)C3=CC=CC=C3
Molecular Formula
C18H20F2N2
Molecular Weight
302.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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