Simufilam hydrochloride
Product Specifications
CAS Number
2480226-07-9
Target
Others, Microtubule Associated, Beta Amyloid, mTOR, iGluR
Related Pathways
Membrane transporter/Ion channel, Cytoskeletal Signaling, Neuroscience, Others, PI3K/Akt/mTOR signaling
Bioactivity
Simufilam (PTI-125) (hydrochloride) is an orally active filamin A (FLNA) activator with low toxicity that can be used in the Alzheimer's disease research. Simufilam (hydrochloride) preferentially binds to altered FLNA and restores its native conformation, restores receptor and synaptic activities, and reduces its a7nAChR/TLR4 associations and downstream pathologies [1].
Smiles
Cl.CN1CCC2(CC1)NCC(=O)N2Cc1ccccc1
Molecular Formula
C15H22ClN3O
Molecular Weight
295.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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