URMC-099
Product Specifications
CAS Number
1229582-33-5
Target
Syk, Src, Trk receptor, IGF-1R, Bcr-Abl, CDK, SGK, ROCK, VEGFR, DNA Alkylation, MLK, LRRK2, Aurora Kinase, c-Met/HGFR, MEK, Autophagy
Related Pathways
Stem Cells, DNA Damage/DNA Repair, Metabolism, Autophagy, Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, MAPK, Cell Cycle/Checkpoint
Purity
0.9998
Bioactivity
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM) .
Smiles
CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Molecular Formula
C27H27N5
Molecular Weight
421.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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