URMC-099
Product Specifications
CAS Number
1229582-33-5
Target
Syk|||Src|||Trk receptor|||IGF-1R|||Bcr-Abl|||CDK|||SGK|||ROCK|||VEGFR|||DNA Alkylation|||MLK|||LRRK2|||Aurora Kinase|||c-Met/HGFR|||MEK|||Autophagy
Related Pathways
Stem Cells|||DNA Damage/DNA Repair|||Metabolism|||Autophagy|||Cytoskeletal Signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||MAPK|||Cell Cycle/Checkpoint
Purity
0.9998
Bioactivity
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM) .
Smiles
CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1
Molecular Formula
C27H27N5
Molecular Weight
421.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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