DIF-3
Product Specifications
CAS Number
113411-17-9
Target
GSK-3, Wnt/beta-catenin, CDK
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells, Cytoskeletal Signaling, Cell Cycle/Checkpoint
Purity
0.9957
Bioactivity
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].
Smiles
CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
Molecular Formula
C13H17ClO4
Molecular Weight
272.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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