CAY10789
Product Specifications
CAS Number
123226-28-8
Target
Others, Leukotriene Receptor, TNF, GPCR19
Related Pathways
Others, Apoptosis, GPCR/G Protein
Bioactivity
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 μM and a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 μM. It significantly decreases U937 cell adhesion to HAEC and reduces TNF-α expression. CAY10789 demonstrates promising metabolic stability and excellent pharmacokinetics, making it suitable for studying colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases [1].
Smiles
C(OC1=CC(CO)=CC=C1)C2=NC3=C(C=C2)C=CC=C3
Molecular Formula
C17H15NO2
Molecular Weight
265.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV711417 1.0 µg DNA
IL21 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details K6959405 3x 1.0 µg
Spdya sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details 
MBS1003560-01 0.02 mg (E-Coli)
Recombinant Yersinia pestis Low calcium response locus protein R (lcrR)
Sign In for Pricing
View Details