CAY10789
Product Specifications
CAS Number
123226-28-8
Target
Others|||Leukotriene Receptor|||TNF|||GPCR19
Related Pathways
Others|||Apoptosis|||GPCR/G Protein
Bioactivity
CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 ?M and a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 ?M. It significantly decreases U937 cell adhesion to HAEC and reduces TNF-? expression. CAY10789 demonstrates promising metabolic stability and excellent pharmacokinetics, making it suitable for studying colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases [1].
Smiles
C(OC1=CC(CO)=CC=C1)C2=NC3=C(C=C2)C=CC=C3
Molecular Formula
C17H15NO2
Molecular Weight
265.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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