Nrf2-ARE/hMAO-B/QR2 modulator 1
Product Specifications
CAS Number
3035124-25-2
Target
MAO, NADPH, Reactive Oxygen Species, Monoamine Oxidase, ROS, Nrf2
Related Pathways
NF-κB, Immunology/Inflammation, Neuroscience, Metabolism
Purity
0.985
Bioactivity
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2 (quinone reductase-2, NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
Smiles
COC1=CC=C(/C=C/C2=NN(CC#C)C(O2)=O)C=C1
Molecular Formula
C14H12N2O3
Molecular Weight
256.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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