N1, N11-Diethylnorspermine
Product Specifications
CAS Number
121749-39-1
Target
Others, Caspase, mTOR
Related Pathways
Proteases/Proteasome, Others, PI3K/Akt/mTOR signaling, Apoptosis
Bioactivity
N1, N11-Diethylnorspermine (DENSPM), a spermine analog, serves as a potent anticancer agent by activating polyamine catabolism, which in turn triggers cytochrome c release from mitochondria and activates caspase 3. This process ultimately leads to the death of glioblastoma multiforme (GBM) cells by inducing spermidine/spermine N1-acetyltransferase (SSAT) activity along with the production of H2O2 [1] [2] [3].
Smiles
C(CNCCCNCC)CNCCCNCC
Molecular Formula
C13H32N4
Molecular Weight
244.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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