CCR4 antagonist 3-1
Product Specifications
CAS Number
1957-01-3
Target
CCR
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology
Purity
0.9987
Bioactivity
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.
Smiles
N(C=1C2=C(C=CC1)C=CC=C2)C3=NC(C)=CS3
Molecular Formula
C14H12N2S
Molecular Weight
240.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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