Nutlin-3a
Product Specifications
CAS Number
675576-98-4
Target
Apoptosis|||E1/E2/E3 Enzyme|||Autophagy|||MDM-2/p53
Related Pathways
Autophagy|||Apoptosis|||Ubiquitination
Purity
0.9971
Bioactivity
Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.
Smiles
COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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