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Linsitinib

Product Specifications

CAS Number

867160-71-2

Target

IGF-1R

Related Pathways

Tyrosine Kinase/Adaptors

Purity

0.9992

Bioactivity

OSI-906 (Linsitinib (OSI-906) ) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

Smiles

NC=1C=2N(C(=NC2C3=CC4=C(C=C3)C=CC(=N4)C5=CC=CC=C5)[C@H]6C[C@@](C)(O)C6)C=CN1

Molecular Formula

C26H23N5O

Molecular Weight

421.49

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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