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VB124

Product Specifications

CAS Number

2230186-18-0

Target

Monocarboxylate transporter

Related Pathways

Membrane transporter/Ion channel

Purity

0.9957

Bioactivity

VB124 is an orally active, potent and selective MCT4 inhibitor. VB124 blocked lactate import (IC50 value of 8.6 nM) and export (IC50 value of 19 nM) in MDA-MB-231 cells. VB124 is selective for MCT4 over MCT1 and shows minimal MCT1 inhibitory activity in MCT1-expressing BT20 cells (IC50 value of 24 μM) .

Smiles

CC(C)(OCc1cc(-c2cccc(OC3CC3)c2)n(n1)-c1ccccc1Cl)C(O)=O

Molecular Formula

C23H23ClN2O4

Molecular Weight

426.89

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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