VB124
Product Specifications
CAS Number
2230186-18-0
Target
Monocarboxylate transporter
Related Pathways
Membrane transporter/Ion channel
Purity
0.9957
Bioactivity
VB124 is an orally active, potent and selective MCT4 inhibitor. VB124 blocked lactate import (IC50 value of 8.6 nM) and export (IC50 value of 19 nM) in MDA-MB-231 cells. VB124 is selective for MCT4 over MCT1 and shows minimal MCT1 inhibitory activity in MCT1-expressing BT20 cells (IC50 value of 24 μM) .
Smiles
CC(C)(OCc1cc(-c2cccc(OC3CC3)c2)n(n1)-c1ccccc1Cl)C(O)=O
Molecular Formula
C23H23ClN2O4
Molecular Weight
426.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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