(1S,2R) -Alicapistat
Product Specifications
CAS Number
2221010-57-5
Target
Cysteine Protease, Proteasome
Related Pathways
Ubiquitination, Proteases/Proteasome
Purity
0.996
Bioactivity
(1S,2R) -Alicapistat ((1S,2R) -ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, showing promise for Alzheimer's disease (AD) therapy [1]. It effectively addresses the metabolic liability associated with carbonyl reduction and demonstrates potent inhibition of calpain 1 with an IC50 value of 395 nM [2].
Smiles
O=C(N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1)[C@H]1CCC(=O)N1Cc1ccccc1
Molecular Formula
C25H27N3O4
Molecular Weight
433.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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