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(1S,2R) -Alicapistat

Product Specifications

CAS Number

2221010-57-5

Target

Cysteine Protease, Proteasome

Related Pathways

Ubiquitination, Proteases/Proteasome

Purity

0.996

Bioactivity

(1S,2R) -Alicapistat ((1S,2R) -ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, showing promise for Alzheimer's disease (AD) therapy [1]. It effectively addresses the metabolic liability associated with carbonyl reduction and demonstrates potent inhibition of calpain 1 with an IC50 value of 395 nM [2].

Smiles

O=C(N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1)[C@H]1CCC(=O)N1Cc1ccccc1

Molecular Formula

C25H27N3O4

Molecular Weight

433.5

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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