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Oritinib

Product Specifications

CAS Number

2035089-28-0

Target

EGFR

Related Pathways

JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

Purity

0.9962

Bioactivity

Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can be used in studies about the treatment of non-small cell lung cancer.

Smiles

COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c2CCCCn2c2ccccc12

Molecular Formula

C31H37N7O2

Molecular Weight

539.67

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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