Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SAR247799

SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome[1][2][3][4].

Product Specifications

CAS Number

1315311-14-8

Product Name Alternative

S1P1 agonist 3

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sar247799.html

Concentration

10mM

Purity

99.38

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=C(C)C=C(C2=NC3=CN=C(OC4=CC=CC(Cl)=C4)N=C3O2)C=C1C

Molecular Formula

C21H16ClN3O5

Molecular Weight

425.82

References & Citations

[1]Bergougnan L, et al. First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection. Br J Clin Pharmacol. 2021 Feb;87 (2) :598-611.|[2]Poirier B, et al. A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers. Sci Signal. 2020 Jun 2;13 (634) :eaax8050.|[3]Evaristi MF, et al. A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome. PLoS One. 2022 Jan 14;17 (1) :e0257929.|[4]Bergougnan L, et al. Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. Br J Clin Pharmacol. 2021 May;87 (5) :2303-2320.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

S1PR1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Sulfolane
TRC-S689220-500G 500 g

Sulfolane

Sign In for Pricing
View Details
PE/Cyanine7 Armenian Hamster IgG Isotype Control[PIP]
E-AB-F09853H-01 25 µg

PE/Cyanine7 Armenian Hamster IgG Isotype Control[PIP]

Sign In for Pricing
View Details
PE/Cyanine7 Armenian Hamster IgG Isotype Control[PIP]
E-AB-F09853H-02 100 µg

PE/Cyanine7 Armenian Hamster IgG Isotype Control[PIP]

Sign In for Pricing
View Details
ABO (NM_020469) Human Recombinant Protein
TP310203M 100 µg

ABO (NM_020469) Human Recombinant Protein

Sign In for Pricing
View Details
Recombinant Rab27A Antibody
RC-15099-01 50 μL

Recombinant Rab27A Antibody

Sign In for Pricing
View Details
Recombinant Rab27A Antibody
RC-15099-02 100 µL

Recombinant Rab27A Antibody

Sign In for Pricing
View Details