NCT02
Product Specifications
CAS Number
790245-61-3
Target
Others, Molecular Glues, CDK
Related Pathways
Others, Cell Cycle/Checkpoint, PROTAC
Bioactivity
NCT02 is a molecular glue degrader targeting CDK12 and CCNK (cyclin K), inducing CCNK ubiquitination and inhibiting CRC cell proliferation in vivo and in vitro, leading to apoptosis and cell cycle arrest. It is intended for the investigation of metastatic colorectal cancer (CRC) .
Smiles
Cc1cnc(NC(=O)Cc2coc3cc4CCCc4cc23)s1
Molecular Formula
C17H16N2O2S
Molecular Weight
312.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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