PF-5274857
Product Specifications
CAS Number
1373615-35-0
Target
Smo
Related Pathways
Stem Cells
Purity
0.9899
Bioactivity
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM) . PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
Smiles
Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
Molecular Formula
C20H25ClN4O3S
Molecular Weight
436.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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