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BI-3802

Product Specifications

CAS Number

2166387-65-9

Target

Bcl-2 Family, Molecular Glues, Bcl-6

Related Pathways

PROTAC, Apoptosis, Immunology/Inflammation

Purity

0.9948

Bioactivity

BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependent on the E3 ligase SIAH1, demonstrating notable antitumor activity[1][2].

Smiles

CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3C[C@@H](C)C[C@@H](C)C3)ccc2n(C)c1=O

Molecular Formula

C24H29ClN6O3

Molecular Weight

484.98

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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