YZ129
Product Specifications
CAS Number
1643120-60-8
Target
Others|||Apoptosis|||HSP
Related Pathways
Metabolism|||Apoptosis|||Others|||Cytoskeletal Signaling
Bioactivity
YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest at the G2/M phase in GBM cells, leading to apoptosis and inhibiting tumor cell proliferation and migration [1].
Smiles
O=C1C=C(Nc2ccc3cnccc3c2)c2ccccc2C1=O
Molecular Formula
C19H12N2O2
Molecular Weight
300.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
sc-494523 5 mg
N- (2-fluorophenyl) -3- (3-methylphenyl) -2- (2H-tetrazol-5-yl) propanamide
Ask
View Details