Alofanib
Product Specifications
CAS Number
1612888-66-0
Target
Apoptosis, FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Purity
0.9981
Bioactivity
Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM) . It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
Smiles
Cc1cc(c(NS(=O)(=O)c2cccc(c2)C(O)=O)cc1-c1cccnc1)[N+]([O-])=O
Molecular Formula
C19H15N3O6S
Molecular Weight
413.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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