Avapritinib
Product Specifications
CAS Number
1703793-34-3
Target
PDGFR|||c-Kit
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.997
Bioactivity
Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.
Smiles
Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Molecular Formula
C26H27FN10
Molecular Weight
498.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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