Avapritinib
Product Specifications
CAS Number
1703793-34-3
Target
PDGFR|||c-Kit
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.997
Bioactivity
Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.
Smiles
Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Molecular Formula
C26H27FN10
Molecular Weight
498.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2038051-01 0.1 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details 
MBS2038051-02 0.2 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details 
MBS2038051-03 0.5 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details MBS2038051-04 1 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details MBS2038051-05 5 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details MBS2038051-06 5x 5 mL
APC/CY7-Linked Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3)
Ask
View Details