(±) -Praeruptorin A
Product Specifications
CAS Number
73069-25-7
Target
Interleukin, NF-κB, p38 MAPK, Akt, Calcium Channel
Related Pathways
Cytoskeletal Signaling, Metabolism, PI3K/Akt/mTOR signaling, Membrane transporter/Ion channel, MAPK, Immunology/Inflammation, NF-κB
Purity
0.9973
Bioactivity
1. (±) -Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca (2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca (2+) /calmodulin-CaMKIV-CREB-NFATc1 and/or Ca (2+) /calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
Smiles
C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Molecular Formula
C21H22O7
Molecular Weight
386.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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