Bis-T-23

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) [1][2].

Product Specifications

CAS Number

[171674-76-3]

Product Name Alternative

AG1717

UNSPSC

12352005

Target

Dynamin; HIV Integrase

Type

Reference compound

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bis-t-23.html

Purity

96.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O

Molecular Formula

C23H20N4O8

Molecular Weight

480.43

References & Citations

[1]Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21 (6) :601-609.|[2]Mazumder, A., et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34 (46), 15111–15122.