25-Hydroxycholesterol
Product Specifications
CAS Number
2140-46-7
Target
HMG-CoA Reductase, Endogenous Metabolite
Related Pathways
Metabolism
Purity
0.9989
Bioactivity
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs) . It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Smiles
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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