1,3,5-Trihydroxy-4-prenylxanthone
Product Specifications
CAS Number
53377-61-0
Target
Sodium Channel, PDE, NO Synthase
Related Pathways
Immunology/Inflammation, Metabolism, Membrane transporter/Ion channel
Bioactivity
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 3.0 μM; it exhibits in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. It also inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1, disrupting TAK1-mediated activation of IKK and MAPKs signal transduction.
Smiles
C(C=C(C)C)C1=C2C(C(=O)C=3C(O2)=C(O)C=CC3)=C(O)C=C1O
Molecular Formula
C18H16O5
Molecular Weight
312.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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