BMS202 hydrochloride (1675203-84-5 (free base) )
Product Specifications
CAS Number
2089334-95-0
Target
Apoptosis|||PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation
Purity
0.9947
Bioactivity
BMS202 hydrochloride (1675203-84-5 (free base) ) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM) . Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
Smiles
Cl.COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O
Molecular Formula
C25H30ClN3O3
Molecular Weight
455.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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