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BMS202 hydrochloride (1675203-84-5 (free base) )

Product Specifications

CAS Number

2089334-95-0

Target

Apoptosis|||PD-1/PD-L1

Related Pathways

Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation

Purity

0.9947

Bioactivity

BMS202 hydrochloride (1675203-84-5 (free base) ) (PD-1/PD-L1 inhibitor 2 hydrochloride) is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM) . Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

Smiles

Cl.COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O

Molecular Formula

C25H30ClN3O3

Molecular Weight

455.97

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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