Ro5-3335
Product Specifications
CAS Number
30195-30-3
Target
Others, DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint
Purity
0.9995
Bioactivity
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM) . Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
Smiles
Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1
Molecular Formula
C13H10ClN3O
Molecular Weight
259.69
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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