Simeprevir

923604-59-5

DNA/RNA Synthesis, SARS-CoV, HCV Protease

Proteases/Proteasome, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Microbiology/Virology

0.9992

Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.

COc1ccc2c(O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(C)CCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(=O)NS(=O)(=O)C3CC3)cc(nc2c1C)-c1nc(cs1)C(C)C

C38H47N5O7S2

749.94

Ice Packs

-20°C