SB297006
Product Specifications
CAS Number
58816-69-6
Target
CCR
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology
Purity
0.9965
Bioactivity
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg) .
Smiles
CCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccccc1
Molecular Formula
C18H18N2O5
Molecular Weight
342.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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