Brevilin A
Product Specifications
CAS Number
16503-32-5
Target
Anti-infection, Apoptosis, JAK, Autophagy, STAT
Related Pathways
Autophagy, Angiogenesis, Stem Cells, Apoptosis, Microbiology/Virology, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling
Purity
>99.99%
Bioactivity
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour
Smiles
[H][C@@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(=O)C(\C)=C/C)[C@]1([H])[C@H](C)C(=O)O2
Molecular Formula
C20H26O5
Molecular Weight
346.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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