WHI-P97 HCl
Product Specifications
Target
JAK
Related Pathways
Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis
Purity
0.9949
Bioactivity
WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
Smiles
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC.Cl
Molecular Formula
C16H14Br2ClN3O3
Molecular Weight
491.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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