WHI-P97
Product Specifications
CAS Number
211555-05-4
Target
JAK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic
Purity
0.9993
Bioactivity
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.
Smiles
COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
Molecular Formula
C16H13Br2N3O3
Molecular Weight
455.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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