NS309
Product Specifications
CAS Number
18711-16-5
Target
Potassium Channel|||EGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Membrane transporter/Ion channel
Purity
0.9755
Bioactivity
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 ?M for SK channels and 10-90 nM for IK channels) . It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 ?M), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
Smiles
ON=C1C(=O)Nc2c1ccc(Cl)c2Cl
Molecular Formula
C8H4Cl2N2O2
Molecular Weight
231.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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