Sulfaphenazole
Product Specifications
CAS Number
526-08-9
Target
Necroptosis, Apoptosis, Cytochromes P450, Antibacterial, Antibiotic
Related Pathways
Apoptosis, Metabolism, Microbiology/Virology
Purity
0.9997
Bioactivity
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19) . At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
Smiles
NC1=CC=C(C=C1)S(=O)(=O)NC1=CC=NN1C1=CC=CC=C1
Molecular Formula
C15H14N4O2S
Molecular Weight
314.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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