Ethacrynic acid
Product Specifications
CAS Number
58-54-8
Target
NF-κB, Calcium Channel, Wnt/beta-catenin, GST, NO Synthase
Related Pathways
Membrane transporter/Ion channel, Cytoskeletal Signaling, Immunology/Inflammation, Metabolism, Oxidation-Reduction, NF-κB, Stem Cells
Purity
>99.99%
Bioactivity
Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.
Smiles
CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl
Molecular Formula
C13H12Cl2O4
Molecular Weight
303.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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