Talniflumate
Product Specifications
CAS Number
66898-62-2
Target
COX, Anion Exchanger, Chloride channel, N-Acetylglucosaminyltransferase
Related Pathways
Immunology/Inflammation, Membrane transporter/Ion channel, Neuroscience, Metabolism
Purity
0.9993
Bioactivity
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
Smiles
O(C(=O)C1=C(NC2=CC(C(F)(F)F)=CC=C2)N=CC=C1)C3C=4C(C(=O)O3)=CC=CC4
Molecular Formula
C21H13F3N2O4
Molecular Weight
414.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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