E7449
Product Specifications
CAS Number
1140964-99-3
Target
PARP
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Purity
0.9782
Bioactivity
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
Smiles
O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23
Molecular Formula
C18H15N5O
Molecular Weight
317.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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CHUK, NT (CHUK, IKKA, TCF16, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, Nuclear factor NF-kappa-B inhibitor kinase alpha, Transcription factor 16)
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View Details MBS6000969-02 5x 0.2 mL
CHUK, NT (CHUK, IKKA, TCF16, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, Nuclear factor NF-kappa-B inhibitor kinase alpha, Transcription factor 16)
Sign In for Pricing
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