E7449

Product Specifications

CAS Number

1140964-99-3

Target

PARP

Related Pathways

DNA Damage/DNA Repair, Chromatin/Epigenetic

Purity

0.97816

Bioactivity

E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.

Smiles

O=c1[nH][nH]c2nc(CN3Cc4ccccc4C3)nc3cccc1c23

Molecular Formula

C18H15N5O

Molecular Weight

317.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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