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Olodanrigan

Product Specifications

CAS Number

1316755-16-4

Target

RAAS

Related Pathways

Endocrinology/Hormones

Purity

0.9833

Bioactivity

Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons induced by AngII. It inhibits capsaicin responses in cultured hDRG neurons.

Smiles

COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1

Molecular Formula

C32H29NO5

Molecular Weight

507.58

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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