Olodanrigan
Product Specifications
CAS Number
1316755-16-4
Target
RAAS
Related Pathways
Endocrinology/Hormones
Purity
0.9833
Bioactivity
Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons induced by AngII. It inhibits capsaicin responses in cultured hDRG neurons.
Smiles
COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Molecular Formula
C32H29NO5
Molecular Weight
507.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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