Poseltinib
Product Specifications
CAS Number
1353552-97-2
Target
Others, TLR, BTK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others, Immunology/Inflammation
Purity
0.9998
Bioactivity
Poseltinib is an orally active, selective, and irreversible inhibitor of Bruton's tyrosine kinase (BTK), with an IC50 value of 1.95 nM. Poseltinib demonstrates 0.3-, 2.3-, and 2.4-fold higher selectivity for BTK over BMX, TEC, and TXK, respectively. Poseltinib covalently binds to cysteine 481 in BTK’s active site, thereby inhibiting BCR-, FcR-, and TLR-mediated signaling pathways.
Smiles
O=C(C=C)NC=1C=CC=C(OC2=NC(=NC=3C=COC23)NC4=CC=C(C=C4)N5CCN(C)CC5)C1
Molecular Formula
C26H26N6O3
Molecular Weight
470.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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