Syk Inhibitor II dihydrochloride
Product Specifications
CAS Number
227449-73-2
Target
5-HT Receptor|||BTK|||PKC|||Tyrosine Kinases|||Syk
Related Pathways
Angiogenesis|||Neuroscience|||Cytoskeletal Signaling|||GPCR/G Protein|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcR? chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKC?, PKC?II, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 ?M, respectively) .
Smiles
Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Molecular Formula
C14H17Cl2F3N6O
Molecular Weight
413.22
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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