ML221
Product Specifications
CAS Number
877636-42-5
Target
Arrestin|||Apelin receptor
Related Pathways
GPCR/G Protein
Purity
0.9774
Bioactivity
ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 ?M in the cAMP assay, and 1.75 ?M in the ?-arrestin assay, and EC80 of 10 nM in both assays.
Smiles
[O-][N+](=O)c1ccc(cc1)C(=O)Oc1coc(CSc2ncccn2)cc1=O
Molecular Formula
C17H11N3O6S
Molecular Weight
385.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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